There has been enormous progress regarding the understanding of T-cell homing within the last decade. It is now possible to identify the multitude of molecules involved, such as cytokines, chemokines, and adhesion molecules, and to unravel their complex interactions resulting in controlled, non-random T-cell recirculation. These insights are now being explored therapeutically, with several compounds close to approval. This book summarizes the key findings in the field, bringing insight not only to the physiology and pathophysiology of T-cell homing as a process, but also to the manipulation of this process for therapeutic benefit.
